Kayamkani Abedulla Khan; Ali Mohamed AlKatsha; Mohammed Abdulghani Sarhan; Fawaz Mashaan Abuhamar; Rawaf Abdulrzaq; Aejaz A. Khan; S. M. Shakeel Iqubal; Muazzam Sheriff Maqbul
Abstract
This study is planned to assess the profile of drug-drug interactions in the medications prescribed to metabolic syndrome patients and also to identify the possible predictors for potential drug-drug interactions. Materials and Methods: A cross-sectional study was conducted from 25th Jan to 1st April ...
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This study is planned to assess the profile of drug-drug interactions in the medications prescribed to metabolic syndrome patients and also to identify the possible predictors for potential drug-drug interactions. Materials and Methods: A cross-sectional study was conducted from 25th Jan to 1st April 2019 to check the drug interactions in ambulatory metabolic syndrome patients in Jeddah, Saudi Arabia. A sample size of 142 patients was included in the study. The prescriptions were analyzed for potential drug interactions using Lexi-Interact Online and Medscape online software to check drug-drug interactions. Results: It is observed that as an average 3.85 drug per prescription was prescribed. We observed 55 prescriptions are containing incomplete patient information that is 48.6% of prescriptions. The 62% of patients of this study were more than 60 years. We found a maximum number of prescriptions were found 4-6 drugs per prescription 60.56 % and 78.12 % interactions were moderate interaction and 3.9 % interaction found were major interactions. Conclusion: It was observed that the number of DDIs increased linearly with the number of drugs and age. The majority of interactions was pharmacodynamic in mechanism and showed moderate severity.
Kayamkani Abedulla Khan; Saif Mohammed Al-ghamdi; Nawaf Mohammed Al-ghamdi; Abdullah Radwan Al-saqqa; Hashim Khalid Halawani; Aejaz A. Khan; S. M. Shakeel Iqubal; Muazzam Sheriff Maqbul; Noorulla Khan Mayana
Abstract
Irrational drug prescribing is considered one of the prime challenges for the healthcare sectors worldwide, leading to baneful outcomes in patients. The World Health Organization (WHO) drug use indicators include prescribing indicators, patient care indicators and facility indicators and prescribing ...
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Irrational drug prescribing is considered one of the prime challenges for the healthcare sectors worldwide, leading to baneful outcomes in patients. The World Health Organization (WHO) drug use indicators include prescribing indicators, patient care indicators and facility indicators and prescribing indicators measure the performance of health care providers in several key dimensions related to the appropriate use of drugs. Patient care indicators are used to understand the way drugs are used. To evaluate the trends and issues related to prescription, patient care and facility at outpatient clinics in Jeddah and to contrast that to the WHO drug use indicators. A Cross-sectional study conducted between January to April 2019. A total of 153 prescriptions were collected from outpatient clinics of private and governmental hospitals were analyzed according to WHO guidelines. The statistical calculations were performed using Microsoft excel software. The results illustrate that the average number of drugs per prescription was 4.56 and the percentage of encounter with antibiotics was 8.4. A comparatively encouraging observations were observed during generic prescribing as it was observed to be 54.2%, the percentage of encounters with injection was 7.8 and the percentage of drugs prescribed from essential drug list (EDL) or formulary was 92%. The prescribed drugs average number per encounter was greater than what was considered ideal according to WHO standards; the other issue found was a lower percentage of generic prescribing compared to WHO ideal value, the rest of prescribing indicators including the prescribing from the essential drug list was almost similar to the ideal value recommended by the WHO (100%).
Muazzam Sheriff Maqbul; Aejaz A. Khan; Tasneem Mohammed; S.M. Shakeel Iqubal; Abdul Rahman Ikbal; Ibrahim Ahmed Shaikh; Uday Muddapur; Mohammed Shahid Hussain; S. K. Singh
Abstract
The oral thrush caused by the cosmopolitan yeast Candida albicans causes pale white cottony patches in the oral regions especially among the Immuno deficient patients. The elderly patients with the diabetes were the main victims of the yeast thrush. The objective of our investigation is to collect the ...
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The oral thrush caused by the cosmopolitan yeast Candida albicans causes pale white cottony patches in the oral regions especially among the Immuno deficient patients. The elderly patients with the diabetes were the main victims of the yeast thrush. The objective of our investigation is to collect the clinical thrush samples from the targeted elderly patients with type 2 diabetes between the age group of 58 to 75 and determine the antifungal activities of Salvia jordanii by employing the standard microbiological technique. The results procured were excellent for the antifungal susceptibility analysis of all five types of S. jordanii essential oil extracts. The MIC and MFC values of the extracts from the Jordanian, Syrian and Moroccan origin shown the same values, whereas the Libyan and Egyptian extract shown the slightly higher values. The nature blessed essential oil extracts got the potential to combat infections as well as to treat the oral thrush. These findings indicate that S. jordanii displays adequate activity against cosmopolitan yeast C. albicans in vitro & its merits. Further analysis to treat yeast associated diseases.
Tasneem Mohammed; Aejaz A. Khan; S. M. Shakeel Iqubal; Touseef Begum
Abstract
Anisoles and Pyridines undergo acetylation and formylation under non-classical Vilsmeier-Haack conditions. The reactants are grinded vigorously in a mortar for about 25 to 30 min at room temperature with a pestle. The introduction of formyl and acetyl groups under solvent free conditions is a unique, ...
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Anisoles and Pyridines undergo acetylation and formylation under non-classical Vilsmeier-Haack conditions. The reactants are grinded vigorously in a mortar for about 25 to 30 min at room temperature with a pestle. The introduction of formyl and acetyl groups under solvent free conditions is a unique, fast and efficient method which has not been reported in literature so far.
Muazzam Sheriff Maqbul; Aejaz A. Khan; Tasneem Mohammed; S.M. Shakeel Iqubal; Abdul Rahman Ikbal; Ibrahim Ahmed Shaikh; Uday Muddapur; Mohammed Shahid Hussain; S. K. Singh
Abstract
The present study showcases the efficacy of Cinnamomum tamala (C. tamala) as a potential antimicrobial substance against the multi-drug resistant Enterococcus faecalis (E. faecalis) bacterium. The one of the most vulnerable bacteria to this spice was E. faecalis but due to lack of authentic evidences ...
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The present study showcases the efficacy of Cinnamomum tamala (C. tamala) as a potential antimicrobial substance against the multi-drug resistant Enterococcus faecalis (E. faecalis) bacterium. The one of the most vulnerable bacteria to this spice was E. faecalis but due to lack of authentic evidences the treatment with this spice was diminished and used as a culinary spice till date to provide flavor without knowing its medicinal values which has given rise to the discovery of synthetic chemical antibiotics to treat these infections. This is an attempt to resurrect the ancient phyto-pharmaceutic techniques for combating the pathogenic bacteria as our time with the synthetic chemical antibiotic drug is draining out which gives rise to the multi-drug bacteria which becomes difficult to be treated. These types of natural resources is an alternate for the toxic synthetic chemicals with zero side effects. Enterococcus faecalis clinical isolate from the different samples showed the best susceptibility with the essential oil extract determined by the Kirby Bauer Disc Diffussion technique with satisfactory MIC and MBC results. The results obtained for the antibacterial properties of Cinnamomum tamala dried leaves essential oil extract recorded were excemplary from the performed standard antibiotic assay which determines that the efficacy of the natural essential oil proved to be an excellent alternative to treat infectious bacterial diseases.
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