Document Type : Research Article
Authors
- Kayamkani Abedulla Khan 1
- Ali Mohamed AlKatsha 1
- Mohammed Abdulghani Sarhan 1
- Fawaz Mashaan Abuhamar 1
- Rawaf Abdulrzaq 1
- Aejaz A. Khan 2
- S. M. Shakeel Iqubal 2
- Muazzam Sheriff Maqbul 3
1 Department of Clinical Pharmacy & Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia
2 Department of General Sciences, Ibn Sina National College for Medical Studies, Jeddah, Kingdom of Saudi Arabia
3 Faculty of Microbiology and Immunology, Ibn Sina National College of Medical Sciences, Al Mahajar Street: 31906, Jeddah 21418, Kingdom of Saudi Arabia
Abstract
This study is planned to assess the profile of drug-drug interactions in the medications prescribed to metabolic syndrome patients and also to identify the possible predictors for potential drug-drug interactions. Materials and Methods: A cross-sectional study was conducted from 25th Jan to 1st April 2019 to check the drug interactions in ambulatory metabolic syndrome patients in Jeddah, Saudi Arabia. A sample size of 142 patients was included in the study. The prescriptions were analyzed for potential drug interactions using Lexi-Interact Online and Medscape online software to check drug-drug interactions. Results: It is observed that as an average 3.85 drug per prescription was prescribed. We observed 55 prescriptions are containing incomplete patient information that is 48.6% of prescriptions. The 62% of patients of this study were more than 60 years. We found a maximum number of prescriptions were found 4-6 drugs per prescription 60.56 % and 78.12 % interactions were moderate interaction and 3.9 % interaction found were major interactions. Conclusion: It was observed that the number of DDIs increased linearly with the number of drugs and age. The majority of interactions was pharmacodynamic in mechanism and showed moderate severity.
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