Document Type : Research Article
Authors
- Gabriela Herrera Rodriguez 1
- Andya J Ramírez Irigoyen 1
- Karla F García Verdugo 1
- Ana V Torres Figueroa 1
- Brianda M Salazar Salas 1
- José C Encinas Encinas 1
- Cinthia Jhovanna Perez Martinez 2
- Teresa del Castillo-Castro 1
1 Departamento de Investigacion en Polímeros y Materiales, Universidad de Sonora, Hermosillo 83000, Sonora, Mexico
2 Departamento de Ciencias Quimico Biologicas, Universidad de Sonora, Hermosillo 83000, Mexico
Abstract
The development of conjugated polymer- and carbonaceous-based platforms as NIR photothermal materials is a valuable contribution to modern-day cancer therapies. Measurements of the thermal response of these materials under same NIR irradiation conditions allows accurately comparing their photothermal capacities to accomplish specific biomedical requirements. In this work, polydopamine (PDA) and polypyrrole (PPy) nanoparticles were synthesized by green-based methods and their photothermal behavior, compared to that of acid-treated carbon nanotubes (CNT), was studied under the same experimental setup. Furthermore, PDA, PPy, and CNT nanostructures were embedded within a crosslinked poly(N-isopropylacrylamide-co-acrylic acid) (P(NIPAM-co-AA)) matrix, and the photothermal properties of these novel nanocomposite hydrogels were also comparatively studied. Experimental conditions such as the filler concentration, irradiation time, and laser power, as well as the nanocomposite hydrogel composition can be tuned to yield mild (39–43 °C) or high (47-50 °C) hyperthermia conditions, as required. The photothermal results of P(NIPAM-co-AA) nanocomposite hydrogels containing PDA, PPy, or CNT nanostructures evidenced the potential of these materials in controlled drug delivery and for combined chemo-photothermal therapies of tumors by NIR laser irradiation.
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