A nanocrystalline titania-based sulfonic acid material was prepared, characterized and used as an effective, efficient and re-usable catalyst for the synthesis of 2-amino-4-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-6-phenyl-4H-pyran-3-carbonitriles and 2-amino-4-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)-6-(pyridin-4-yl)-4H-pyran-3-carbonitrile derivatives under solvent-free conditions.  This simple three component one-pot synthesis results in high yield products in 2 hours via conventional heating protocols.  The catalyst was characterized by XRD, TEM, SEM, BET and Raman spectroscopy. The catalyst was recycled 5 times and recorded a decrease of 10 % in catalytic activity making it cost effective for large scale production.