@article { author = {Murugesan, Arul and M Gengan, Robert and Krishnan, Anand}, title = {Green approach: Nanocrystalline titania-based sulfonic acid catalyst for the synthesis of piperazinyl-quinolinyl pyran derivatives}, journal = {Advanced Materials Letters}, volume = {8}, number = {2}, pages = {128-135}, year = {2017}, publisher = {International Association of Advanced Materials}, issn = {0976-3961}, eissn = {0976-397X}, doi = {10.5185/amlett.2017.7040}, abstract = {A nanocrystalline titania-based sulfonic acid material was prepared, characterized and used as an effective, efficient and re-usable catalyst for the synthesis of 2-amino-4-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-6-phenyl-4H-pyran-3-carbonitriles and 2-amino-4-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)-6-(pyridin-4-yl)-4H-pyran-3-carbonitrile derivatives under solvent-free conditions.  This simple three component one-pot synthesis results in high yield products in 2 hours via conventional heating protocols.  The catalyst was characterized by XRD, TEM, SEM, BET and Raman spectroscopy. The catalyst was recycled 5 times and recorded a decrease of 10 % in catalytic activity making it cost effective for large scale production.}, keywords = {Sulfonic,acid catalyst,Solvent,free,MCR,Knoevenagel condensation}, url = {https://aml.iaamonline.org/article_14976.html}, eprint = {https://aml.iaamonline.org/article_14976_8ba427d7c1cc4d537321bc3eb7f2c86f.pdf} }