Prashanth Gopala Krishna; Prashanth Paduvarahalli Ananthaswamy; Manoj Gadewar; Utpal Bora; Nagabhushana Bhangi Mutta
Abstract
In this study, we report the antibacterial and anticancer activity of ZnO nanoparticles (NPs) prepared by sugar-fueled solution combustion synthesis. The structure and morphology of the sample were determined by XRD, UV-visible, FESEM and HRTEM. Surface area measurement was carried out by standard Brunauer-Emmett-Teller ...
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In this study, we report the antibacterial and anticancer activity of ZnO nanoparticles (NPs) prepared by sugar-fueled solution combustion synthesis. The structure and morphology of the sample were determined by XRD, UV-visible, FESEM and HRTEM. Surface area measurement was carried out by standard Brunauer-Emmett-Teller technique. Antibacterial activity of ZnO NPs was tested against Clostridium perfringens and Salmonella enterica by well diffusion method. The anticancer efficacy of ZnO nanoparticles was carried out on breast cancer cells MCF-7. The antibacterial results affirm that spherical ZnO NPs constitute as a successful bactericidal agent against both Gram-positive and Gram-negative bacteria. Anticancer result indicates that ZnO NPs exert dose dependent toxicity in MCF-7.
Harminder Kaur; Geetanjali Pujari; Asitikantha Sarma; Yogendra Kumar Mishra; Mi Kyung Jin; Bikesh K. Nirala; Nivedita K Gohil; Rainer Adelung; Devesh Kumar Avasthi
Abstract
Gold nanoparticles (AuNPs) are potential candidates for targeted drug delivery, imaging and early detection of cancer cells due to their ability to bind with cancer cells. To ensure their safe use in various possible biomedical applications, it is essential to examine the cytotoxicity and biocompatibility ...
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Gold nanoparticles (AuNPs) are potential candidates for targeted drug delivery, imaging and early detection of cancer cells due to their ability to bind with cancer cells. To ensure their safe use in various possible biomedical applications, it is essential to examine the cytotoxicity and biocompatibility of AuNPs before use. The present work aims to study the cytotoxicity of glucose capped gold nanoparticles (Glu-AuNPs) in several cell lines (HeLa, A549, Jurkat, L929 and HUVEC). The synthesized Glu-AuNPs, using β-D glucose as reducing as well as capping agent, were characterized by SPR and TEM/EDAX analysis. Internalization of Glu-AuNPs in cells was studied by cross sectional TEM imaging. The cytotoxicity of Glu-AuNPs was evaluated by means of colony formation and MTT assays. The present study reveals that Glu-AuNPs (7±2 nm diameter) are non-toxic to the above-mentioned five cell lines, which are cancerous cell lines except HUVEC. Therefore Glu-AuNPs (around 7nm) can be explored for various bio-medical applications and can be of importance for therapeutic applications as evident from enhancement in radiosensitization from our previous work.