Keywords : glucose sensor


Glucose detection via Ru-mediated catalytic reaction of glucose dehydrogenase

Won-Yong Jeon; Chang-Jun Lee;Hyug-Han Kim; Young-Bong Choi; Bo-Hee Lee; Ho-Jin Jo; Soo-Yeon Jeon

Advanced Materials Letters, 2018, Volume 9, Issue 3, Pages 220-224
DOI: 10.5185/amlett.2018.1947

In the electrochemical glucose sensor field, glucose dehydrogenase (GDH) has attracted attention as an enzyme alternative to glucose oxidase (GOD), which suffers performance issues due to variability in oxygen concentrations. The typical mediator used with GOD in electrochemical glucose sensors, hexamine ([Ru(dmo-bpy)2Cl2]), was synthesized and applied to facilitate electron transfer between GDH and the electrode. The prepared [Ru(dmo-bpy)2Cl2] was examined physicochemically by NMR, UV-vis, and XPS spectroscopy, and electrochemically by CV. Then, GDH and a cross linker, poly (ethylene glycol) diglycidyl ether, were adsorbed with [Ru(dmo-bpy)2Cl2] onto a screen-printed carbon electrode. The glucose response of [Ru(dmo-bpy)2Cl2] with GDH as an electron-transfer mediator was investigated by potentiostat. The resulting electrical currents were well correlated (R 2 = 0.9984) with glucose concentration (5.0, 10.0, 15.0, and 30.0 mM). Therefore, this ruthenium complex can be used for glucose detection with GDH as a good substitute mediator.

Polypyrrole-Pt Nanocomposites As Electrochemical Glucose Sensor

Nitin R. Dighore; Suresh T. Gaikwad; Anjali S. Rajbhoj

Advanced Materials Letters, 2016, Volume 7, Issue 12, Pages 1035-1039
DOI: 10.5185/amlett.2016.6561

A voltammetric sensor was developed for detection of glucose by using cyclic voltammetry (CV). The sensing platform was Polypyrrole-Pt nanocomposites on Platinum electrode (PPy-Pt-PtE). PPy-Pt was synthesized by chemical method, using FeCl3 oxidant. XRD, SEM and TEM results showed that PPy doped with Pt were highly porous, nanocrystalline composites. The PPy-Pt-PtE modified electrode observed reversible behavior with ferricyanide system which had about 2.05 times more surface area and exhibited higher currents for glucose oxidation compared to bare PtE. Glucose was sensed in the range of 100mM to 1000 mM from the linear regression plotted R 2 = 0.990 and R 2 = 0.994 the sensitivity was found to be 0.047 mA/mM~cm 2 and 0.0445 mA/mM~cm 2 . These results indicate that PPy-Pt-PtE exhibited good platform and could be used for voltammetric determination of glucose.