Keywords : electrochemical analysis


Novel Poly(pyrrole-co-3-acetyl pyrrole)-WO3 nanocomposites modified gold electrode as electrocatalytic oxidation and reduction of H2O2

Nitin Dighore; Priya Dahare; Suresh Gaikwad; Anjali Rajbhoj

Advanced Materials Letters, 2021, Volume 12, Issue 10, Pages 1-6
DOI: 10.5185/aml.2021.15703

The fabrication of an electrochemical sensor based on novel poly(pyrrole-co-3acetyl pyrrole)-WO3 nanocomposites modified gold electrode (PPAP-WO3-AuE) and its electrocatalytic oxidation and reduction of hydrogen peroxide is described here. The PPAP-WO3 nanocomposites were synthesized by chemical method and characterized by different techniques. The WO3 nanoparticles incorporated with PPAP were confirmed by x-ray diffraction pattern, scanning electron microscopy and transmission electron microscope micrograph. The electrochemical behaviour of PPAP-WO3-AuE towards the electro catalytic oxidation and reduction of hydrogen peroxide was investigated by cyclic voltammetry, differential pulse voltammetry and square wave voltammetry. The observed DPVs and SWVs response depend linearly on concentration of hydrogen peroxide in the range of 1-10 mM and with limit of detection (LOD) is 1×10-4 M. The correlation coefficients were found as 0.991, 0.930 and sensitivity observed was 47.64 mA/mM.cm2 and 8.31mA/mM.cm2. These results indicate the PPAP-WO3-AuE exhibited good platform and could be used for electrochemical determination of hydrogen peroxide.

Gold nanoparticle-based biosensors for the assay of tumor marker proteins with clinical applications

Jiehua Ma; Xiaolu Hu; Yaqin Tao; Chao Li; Xiaoxia Mao; Genxi Li

Advanced Materials Letters, 2017, Volume 8, Issue 12, Pages 1125-1131
DOI: 10.5185/amlett.2017.1552

The detection of tumor markers plays an important role in clinical diagnosis and evaluation of therapeutic effect. Early detection of tumor markers, which are usually proteins, can greatly facilitate effective treatment with different modalities and even increase cure rate of patients. Currently, nanoparticle-based methods for cancer diagnostics are becoming an increasingly relevant alternative to traditional techniques. Gold nanoparticles (AuNPs) are one of the most extensively studied nanomaterials due to their remarkable physical and chemical properties. With the recent advances in nanotechnology, AuNPs have offered new ways to detect tumor markers at low concentrations and to target cancer cells in very deep sites. The use of AuNPs may increase the sensitivity of a biosensor and generate higher accuracy and precision of the assays. So, AuNPs have greatly facilitated the development of nanomaterials-based technology for clinic diagnostics and therapy. In this review paper, we have summarized different kinds of AuNPs-based biosensors for the detection of tumor marker proteins with a particular focus on optical and electrochemical techniques, which may provide valuable perspective for the colleagues in the related communities.

Polypyrrole-Pd nanocomposites modified gold electrode for electrochemical detection of ascorbic acid

Nitin R. Dighore; Suresh T. Gaikwad; Anjali S. Rajbhoj

Advanced Materials Letters, 2017, Volume 8, Issue 7, Pages 762-767
DOI: 10.5185/amlett.2017.6987

The fabrication of an electrochemical sensor based on polypyrrole-Pd nanocomposites modified gold electrode (PPy-Pd-AuE) and its electrodetection of ascorbic acid is described. The PPy-Pd nanocomposites were synthesized by chemical method and characterized by different techniques. The Pd nanoparticles incorporated with PPy were confirmed by x-ray diffraction, scanning electron microscope, elemental dispersive spectroscopy and transmission electron microscopy analysis. The electrochemical behavior of polypyrrole-Pd nanocomposites towards the electro catalytic oxidation of ascorbic acid was investigated by cyclic voltammetry, differential pulse voltammetry and square wave voltammetry. The observed cyclic voltammetry, differential pulse voltammetry and square wave voltammetry response depended linearly on concentration of ascorbic acid in the range of 100-1000 mM with correlation coefficients of R 2 =0.977, R 2 =0.980, R 2 = 0.990 and sensitivity 7.96 mA/mM.cm 2 , 0.70 mA/mM.cm 2 and 2.10 mA/mM.cm 2 respectively. The reproducibility of PPy-Pd-AuE electrode from CV, DPV and SWV were found to be 3.9%, 4.69% and 2.98 % respectively. These results indicate the PPy-Pd-AuE exhibited excellent platform and could be used for electrochemical determination of ascorbic acid. 

Polypyrrole-Pt Nanocomposites As Electrochemical Glucose Sensor

Nitin R. Dighore; Suresh T. Gaikwad; Anjali S. Rajbhoj

Advanced Materials Letters, 2016, Volume 7, Issue 12, Pages 1035-1039
DOI: 10.5185/amlett.2016.6561

A voltammetric sensor was developed for detection of glucose by using cyclic voltammetry (CV). The sensing platform was Polypyrrole-Pt nanocomposites on Platinum electrode (PPy-Pt-PtE). PPy-Pt was synthesized by chemical method, using FeCl3 oxidant. XRD, SEM and TEM results showed that PPy doped with Pt were highly porous, nanocrystalline composites. The PPy-Pt-PtE modified electrode observed reversible behavior with ferricyanide system which had about 2.05 times more surface area and exhibited higher currents for glucose oxidation compared to bare PtE. Glucose was sensed in the range of 100mM to 1000 mM from the linear regression plotted R 2 = 0.990 and R 2 = 0.994 the sensitivity was found to be 0.047 mA/mM~cm 2 and 0.0445 mA/mM~cm 2 . These results indicate that PPy-Pt-PtE exhibited good platform and could be used for voltammetric determination of glucose.