Rosa D
Abstract
Noble metal nanostructures have demonstrated many intriguing features for both therapy and diagnosis in a number of diseases. However, their clinical translation is prevented by their accumulation in organisms that can result in toxicity and interference with common medical diagnoses. In order to combine ...
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Noble metal nanostructures have demonstrated many intriguing features for both therapy and diagnosis in a number of diseases. However, their clinical translation is prevented by their accumulation in organisms that can result in toxicity and interference with common medical diagnoses. In order to combine the most interesting behaviour of metal nanoparticles with the possibility of their body clearance, we have recently introduced and tested the passion fruit-like nano-architectures. They are versatile 100 nm biodegradable nanostructures composed by a silica shell embedding functional polymeric arrays of ultra-small noble metal nanoparticles. Here, we report a novel simple and robust protocol to increase the loading of ultra small gold nanoparticles in the nano-architectures, promoting their possible application in clinical diagnosis.
Amineh Ghaderi; Yugal Agrawal;Ashutosh Tiwari; Eduardo Antunez de Mayolo; Hirak Kumar Patra; Mohsen Golabi; Onur Parlak; Rickard Gunnarsson; Raul Campos; Revuri Vishnu; Sami Elhag; Selvakumar Subramanain; Wetra Yandi; Yuan Liu
Abstract
Nanoscale theragnosis is the biomedical aspect of nanomaterials for simultaneous diagnosis and therapy. The last decade was completely devoted by the scientist to combine the advancement in nanotechnology molecular biotechnology for the development of future nanomedicine. The approach started with the ...
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Nanoscale theragnosis is the biomedical aspect of nanomaterials for simultaneous diagnosis and therapy. The last decade was completely devoted by the scientist to combine the advancement in nanotechnology molecular biotechnology for the development of future nanomedicine. The approach started with the development of target-specific delivery of the cargo imaging molecule or drugs for biomedical applications. The cutting edge advantages of the nanoscale materials (e.g., large surface to volume ratio, size-shape dependent physicochemical properties and multi-functionality etc.) proved themselves as the most potential preferences to design optimal therapy for the personalized medicine. The present tutorial review will highlight the recent advances in the development on the regulation of such theragnosis system and their biomedical perspectives to act as a future nanomedicine.
Umesh Kumar Parida; S. K. Biswal; B.K. Bindhani
Abstract
Gold nanoparticles (AuNPs) have found widespread applications in life sciences. Gold nanoparticles are of interest because of the unique properties which can be incorporated into cancer therapy applications, biosensor materials, composite fibers, cryogenic superconducting materials, cosmetic products, ...
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Gold nanoparticles (AuNPs) have found widespread applications in life sciences. Gold nanoparticles are of interest because of the unique properties which can be incorporated into cancer therapy applications, biosensor materials, composite fibers, cryogenic superconducting materials, cosmetic products, and electronic components. In the present research program, cost effective and environment friendly gold nanoparticles were synthesized using red grape pomace (GPM) ethanolic extract as a reducing agent and a capping agent. The nanoparticles were characterized using UV-visble, XRD, TEM and DLS methods. The absorption peak at 554 nm was found to be broadening with increase in time indicating the polydispersity nature of the nanoparticles. The XRD results suggested that the crystallization of the bioorganic phase occurs on the surface of the gold nanoparticles or vice versa. The TEM image showed relatively spherical shape nanoparticles. We also Purified anti-OMP85 antibody were successfully conjugated on 13 ± 34 nm gold nanoparticles by an electrostatic adsorption method.
Prashant K. Sharma; Ranu K. Dutta; Avinash C. Pandey
Abstract
Multifunctional magnetic nanoparticles have emerged as one of the important futuristic material for variety of applications starting from data storage, security/sensors to biomedical applications. The application of multifunctional magnetic nanoparticles in biological organisms has fashioned noteworthy ...
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Multifunctional magnetic nanoparticles have emerged as one of the important futuristic material for variety of applications starting from data storage, security/sensors to biomedical applications. The application of multifunctional magnetic nanoparticles in biological organisms has fashioned noteworthy advances in research, diagnosis and therapy of various diseases. The multifunctional magnetic nanoparticles, capable of theragnosis, drug delivery and monitoring of therapeutic response, are expected to play a significant role in the emergence of the era of personalized medicine with much of research efforts devoted toward that goal. The present review recapitulates the development of state-of-the-art multifunctional magnetic nanoparticles and the foremost applications of these multifunctional magnetic nanoparticles in magnetic targeting, drug delivery, separation, and contrast agents in magnetic resonance imaging, hyperthermia and sensors. The biocompatibility requirements and functionalization approach for multifunctional magnetic nanoparticles used in these applications are also reviewed.
Yi Ge; Ashutosh Tiwari;Songjun Li
Abstract
The application of science and technology at the nano-scale is redefining fields like imaging, diagnosis, drug delivery, regenerative medicine and biomaterials as well as underpinning the development of new generations of medical products. Many of these advances would offer vastly improved outcomes for ...
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The application of science and technology at the nano-scale is redefining fields like imaging, diagnosis, drug delivery, regenerative medicine and biomaterials as well as underpinning the development of new generations of medical products. Many of these advances would offer vastly improved outcomes for patients, therapies for hitherto difficult-to-treat diseases or conditions, improved manufacturing efficiency, and better use of valuable medical professional resources. The technology has already found its way into multifarious applications in healthcare such as diagnostic imaging agents, drug delivery systems, pathogen detection systems, biosensors, tissue engineering, microfluidics, lab-on-a-chip, compact electronic systems.