Sayeesh PM; Reshma Joy; Nibisha Pradeep; Franklin John; Jinu George
Abstract
Hydrogel beads based on natural polymers like alginate, κ-Carrageenan, and gelatin represent an efficient scaffold for controlled hydrophobic drug delivery. We report herein the development and characterization different formulations of hydrogel systems based on the above-mentioned polymers having ...
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Hydrogel beads based on natural polymers like alginate, κ-Carrageenan, and gelatin represent an efficient scaffold for controlled hydrophobic drug delivery. We report herein the development and characterization different formulations of hydrogel systems based on the above-mentioned polymers having adequate properties as drug delivery matrices. Different combinations of alginate/κ-Carrageenan and alginate/gelatin hydrogel beads were developed and drug release properties were compared using curcumin as a model drug. Alginate/κ-Carrageenan hydrogel beads with 50:50 weight ratio exhibited higher swelling and better drug release percentage than compared to other beads. Antibacterial activity of curcumin released from hydrogel beads against B. cereus was established by disc assay. Encapsulation efficiency and drug release behaviour of different formulations of alginate/κ-Carrageenan and alginate/gelatin indicates that the polymer blends synthesized possess considerable potential in pharmaceutical and medicinal applications. Copyright © VBRI Press.
Romina P. Ollier*; Jimena S. Gonzalez;Vera A. Alvarez; Laura M. Sanchez
Abstract
Hydrogels are one of the most widely employed materials in biological, medical and technological areas. However, the use of hydrogels sometimes is restricted due to their specific properties. It is well-known that polymeric nanocomposites reinforced with clays show valuable improvements in their properties. ...
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Hydrogels are one of the most widely employed materials in biological, medical and technological areas. However, the use of hydrogels sometimes is restricted due to their specific properties. It is well-known that polymeric nanocomposites reinforced with clays show valuable improvements in their properties. In this work, eco-friendly composite hydrogels were prepared employing polyvinylalcohol (PVA) and bentonite (abundant and low cost smectite-type clay in Argentina) as raw materials through the previously optimized freezing-thawing (F-T) crosslinking method. Different nanocomposite hydrogels were obtained by varying the corresponding reactor feed. These materials have been recently chemically, morphologically and mechanically analysed in a recent work. Specifically, in the present work, thermal degradation behaviour of PVA-bentonite hydrogels was studied. Kinetic analytical models were applied to non-isothermal thermogravimetric (TGA) measurements trying to identify the possible mechanism for PVA degradation in the presence of bentonite.
Anjna Kumari; ;Susheel Kalia; Balbir Singh Kaith; Amar Singh Singha; and Susheel Kalia
Abstract
Psyllium, a medicinally important natural polymer was functionalized with acrylic acid using FAS-H2O2 as redox initiator and glutaraldehyde as a crosslinker. Synthesized hydrogel was characterized with FTIR spectroscopy, SEM and TGA/DTA techniques to know their surface morphology and thermal stability. ...
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Psyllium, a medicinally important natural polymer was functionalized with acrylic acid using FAS-H2O2 as redox initiator and glutaraldehyde as a crosslinker. Synthesized hydrogel was characterized with FTIR spectroscopy, SEM and TGA/DTA techniques to know their surface morphology and thermal stability. Salt resistant swelling behavior of synthesized hydrogel was studied in different salt solutions as a function of concentration of salt, temperature and pH. It was found that synthesized hydrogel showed maximum swelling (514.0 %) in NaCl solution followed by NH4Cl, MgCl2, CaCl2 and BaCl2 solution. Psy-g-poly(AA) hydrogel showed maximum swelling (863.49%) at 30 ºC in distilled water.
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