Arul Murugesan; Robert M Gengan; Kandasamy G Moodley; Gerhard Gericke
Abstract
Boron nitride nanomaterial based solid acid catalyst is an efficient and reusable sulfonic acid catalyst for the one-pot synthesis of 9-(2-(4-ethylpiperazin-1-yl)quinolin-3-yl)-3,3-dimethyl-3,4,9,10-tetrahydroacridin-1(2H)-one derivatives under microwave irradiation conditionsvia. The Knoevenagel and ...
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Boron nitride nanomaterial based solid acid catalyst is an efficient and reusable sulfonic acid catalyst for the one-pot synthesis of 9-(2-(4-ethylpiperazin-1-yl)quinolin-3-yl)-3,3-dimethyl-3,4,9,10-tetrahydroacridin-1(2H)-one derivatives under microwave irradiation conditionsvia. The Knoevenagel and Michael type reactions. The catalyst was prepared by simply mixing boron nitride and 3-amino-4-methoxybenzenesulfonic acid in a safe method. The morphological properties of the catalyst was determined by using FT-IR, XRD, TEM, SEM and Raman spectroscopy. The synthesised catalyst was employed in a Knoevenagel and Michael type reaction to synthesise novel ethylpiperazinyl-quinolinyl based acridine derivatives. Furthermore, the newly-synthesised compounds was used for molecular docking in Hsp90 protein studies. The method developed in this study has the advantages of good yield, simplicity coupled with safety and short reaction time. Most importantly it was found that the solid acid catalyst can be recycled with minimal loss of activity over five cycles.
Arul Murugesan; Robert M Gengan; Anand Krishnan
Abstract
A nanocrystalline titania-based sulfonic acid material was prepared, characterized and used as an effective, efficient and re-usable catalyst for the synthesis of 2-amino-4-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-6-phenyl-4H-pyran-3-carbonitriles and 2-amino-4-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)-6-(pyridin-4-yl)-4H-pyran-3-carbonitrile ...
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A nanocrystalline titania-based sulfonic acid material was prepared, characterized and used as an effective, efficient and re-usable catalyst for the synthesis of 2-amino-4-(2-(4-methylpiperazin-1-yl) quinolin-3-yl)-6-phenyl-4H-pyran-3-carbonitriles and 2-amino-4-(2-(4-methylpiperazin-1-yl)quinolin-3-yl)-6-(pyridin-4-yl)-4H-pyran-3-carbonitrile derivatives under solvent-free conditions. This simple three component one-pot synthesis results in high yield products in 2 hours via conventional heating protocols. The catalyst was characterized by XRD, TEM, SEM, BET and Raman spectroscopy. The catalyst was recycled 5 times and recorded a decrease of 10 % in catalytic activity making it cost effective for large scale production.
