Document Type : Research Article
Authors
1 School of Automation Engineering, University of Electronic Science and Technology of China, China
2 Department of Obstetrics and Gynecology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, China
Abstract
This study aims to explore the unique electrical properties of organic tissue junctions with different electrical properties in an active electric field. In the previous study, we found that the energy spectrum distortion at the junction of pig stomach tissue and pork tissue was different from that of these two tissues, and based on this finding, we proposed the conjecture of biojunction. In order to study the reproducibility of this electrical feature, we use a variety of pig tissues to construct a new composite biological tissue for testing, and the results show that the feature can be reproduced in the artificially constructed composite biological tissue. Meanwhile, in order to study whether this electrical feature will appear at the boundary of naturally formed composite biological tissues and cancer tissues surrounded by normal tissues, we construct a tumor bearing mouse model carrying human ovarian cancer cells and tested it in the active electric field. The results show that this feature also appeared in the in-vivo experiment. Finally, in order to test the availability of the electrical characteristics of the junction of composite biological tissues, the KNN algorithm is used to train and classify the data collected in the experiment of tumor bearing mice, and the junction site and non-junction site of organic tissues are distinguished with a high success rate, showing the potential of this electrical characteristic in detecting the boundary of tumor tissues in clinic.
Graphical Abstract
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Keywords
- Active electric field
- Composite biological tissue
- Electrical characteristics
- Tumor bearing mouse model
Main Subjects
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