Herein, the chemopreventive effect of oral and topical administration of composite of alcoholic plant extracts of Butea monosperma (Lam.) Taub. (BME) leaves and gold nanoparticles (Au NPs) have been investigated. The tumor growth has been initiated by the 7, 12-dimethyl benz (a) anthracene (DMBA) and skin tumorigenesis in male Swiss albino mice were promoted by the 12-O-tetradecanoylphorbol-13-acetate (TPA). However, malignant feature of the skin tumors were treated with composite of (BME-Au NPs) to reduce the tumor incidence, tumor burden, tumor yield, cumulative number of tumors, tumor size, mass, and volume, respectively. Furthermore, studies were extended to treat CML (chronic myeloid leukemia) K562 (blood cancer) cells with the combination of DMBA/TPA-(BME-Au NPs) and it show greater (~80%) cellular inhibition on cancer cells. Compare to BME alone the composite of (BME-Au NPs) shows significant effect on skin carcinoma and as well on cancer cells.