Through this research, the degradation of Tartrazine (TZ) azo-dye in synthetic wastewater solutions, has been examined under the influence of diverse experimental circumstances of ultrasound and ultraviolet irradiation. At small initial concentrations of Tartrazine (TZ) (10ppm), the photochemical process alone was considered efficient for degradation of TZ. However, in the case of sonochemical alone, the degradation continued very gently, resulted in fewer than 53% of Tartrazine (TZ) elimination after 200 min. Whereas, the adding of an oxidant such as H2O2 leads to increasing the degradation efficiency to certain extent. Additional increasing of H2O2 over the optimum concentration decrease the degradation because of the scavenging consequence of excess H2O2.