Ganeshlenin Kandasamy; Atul Sudame; Dipak Maity
Abstract
Herein, we have reported an easy process for the synthesis of superparamagnetic iron oxide nanoparticles (SPIOs, with a size of ~ 10 nm), where these SPIOs are surface-functionalized with novel pi-electron rich surfactants such as 1,4-benzene dicarboxylic acid (BDA) and 2-amino-1,4-benzene dicarboxylic ...
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Herein, we have reported an easy process for the synthesis of superparamagnetic iron oxide nanoparticles (SPIOs, with a size of ~ 10 nm), where these SPIOs are surface-functionalized with novel pi-electron rich surfactants such as 1,4-benzene dicarboxylic acid (BDA) and 2-amino-1,4-benzene dicarboxylic acid (ABDA). The BDA/ABDA capped SPIOs have demonstrated well crystalline character, excellent colloidal stability, and high saturation magnetization. Moreover, these capped SPIOs have shown good heating ability in magnetic-hyperthermia studies under an alternating magnetic field at a medically suitable frequency, as compared to the previously reported SPIOs based heating-agents. Thus, the as-prepared BDA/ABDA-SPIOs can be used as promising heating agents for magnetic-hyperthermia based biomedical applications.
Ganeshlenin Kandasamy; Atul Sudame; Dipak Maity
Abstract
In recent times, superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as heating agents in magnetic hyperthermia therapy (MHT) to kill malignant cells in cancer treatments, which is mainly due to their excellent magnetic properties and biocompatibility. However, it is still a challenge ...
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In recent times, superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as heating agents in magnetic hyperthermia therapy (MHT) to kill malignant cells in cancer treatments, which is mainly due to their excellent magnetic properties and biocompatibility. However, it is still a challenge to coat SPIONs with suitable surfactants and to apply an appropriate alternative magnetic field (AMF) at specific frequency to achieve enhanced heating effects in MHT. In this work, the as-synthesized novel short-chain surfactants (i.e., amino-terephthalic acid (ATA) and terephthalic acid (TA)) coated hydrophilic SPIONs are synthesized and subsequently involved in calorimetric hyperthermia studies to investigate their intrinsic heating capability by varying (i) their concentrations from 1 - 8 mgFe/ml and (ii) AMFs at different frequencies (263.2 – 752.39 kHz) while achieving the temperature above 42 °C – therapeutic hyperthermia temperature. It is found that the heating rate of TA-SPIONs is faster as compared to ATA-SPIONs on exposure to the AMF. However, the highest specific absorption rate (SAR) value of 129.80 W/gFe is attained for ATA-SPIONs with 2 mgFe/ml concentration on exposure to AMF at 752.39 kHz. Thus, ATA/TA coated SPIONs are very promising agents for magnetic hyperthermia and could be further investigated in in vitro/in vivo cancer treatments.
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