T. Muthu; K. Anand; M. Sureshkumar; R. M. Gengan
Abstract
An efficient one-pot multi-component synthesis of medicinally important 2-amino-4H-pyran-3-carbonitrile derivatives using a new heterogeneous calcium loaded boron nitride (CaBNT) catalyst is described herein. This transformation transpires by Knoevenagel condensation, Michael addition and intramolecular ...
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An efficient one-pot multi-component synthesis of medicinally important 2-amino-4H-pyran-3-carbonitrile derivatives using a new heterogeneous calcium loaded boron nitride (CaBNT) catalyst is described herein. This transformation transpires by Knoevenagel condensation, Michael addition and intramolecular cyclization. Alkaline earth metal-based green catalyst was successfully prepared and characterized by XRD, SEM with EDX, Raman spectroscopy, BET, DSC-TGA and FT-IR. The reaction works up is facile and CaBNT catalyst can easily be separated from the reaction mixture and re-used more than five times in subsequent reactions. This methodology offers several advantages such as excellent yields, use of inexpensive solvent and relatively shorter reaction time.
V. Malapermal; J.N. Mbatha; R.M. Gengan; K. Anand
Abstract
This study was aimed at developing a simple, eco-friendly and cost effective green chemistry method for the synthesis of bimetallic Au-Ag nanoparticles using Ocimum basilicum aqueous leaf and flower extracts, respectively as the natural reducing agents. The successive reduction of chloroauric acid and ...
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This study was aimed at developing a simple, eco-friendly and cost effective green chemistry method for the synthesis of bimetallic Au-Ag nanoparticles using Ocimum basilicum aqueous leaf and flower extracts, respectively as the natural reducing agents. The successive reduction of chloroauric acid and silver nitrate led to the formation of Au-Ag nanoparticles within 10 min at room temperature, suggesting a higher reaction rate than chemical methods involved in the synthesis. Stable, spherical nanoparticles with well-defined dimensions of average size of 3-25 nm was confirmed by UV-Visible spectroscopy, TEM, SEM-EDX, DLS, and zeta potential, whilst, FTIR in combination with GC-MS analyzed the functional groups adhered to the surface of the nanoparticles The colloidal suspension displayed enhanced antihyperglycemic activity at 69.97 ± 3.42% (leaf) against α-amylase (from porcine) and at 85.77 ± 5.82% (flower) against Bacillus stearothermophilus α-glucosidase than that of acarbose and their respective crude extracts. Furthermore, revealed good antibacterial activity against bacterial species Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Pseudomonas aeruginosa.
