TY - JOUR ID - 15026 TI - Mixed lipid/polymer nanostructures: From advanced materials to drug delivery systems JO - Advanced Materials Letters JA - AML LA - en SN - 0976-3961 AU - Pippa, Natassa AU - Skandalis, Athanasios AU - Demetzos, Costas AU - Libera, Marcin AU - Marcinkowski, Andrzej AU - Trzebicka, Barbara AD - Y1 - 2017 PY - 2017 VL - 8 IS - 4 SP - 428 EP - 434 KW - Mixed nanostructures KW - Liposomes KW - Polymers KW - Drug delivery KW - fractal dimension DO - 10.5185/amlett.2017.1414 N2 - The aim of this investigation was to study the alterations of the physicochemical characteristics of L-α-phosphatidylcholine, hydrogenated (Soy) (HSPC) and dipalmitoyl phosphatidyl choline (DPPC) liposomes, caused by the incorporation of a poly (oligoethylene glycol acrylate)-b-poly(lauryl acrylate) (POEGA-PLA) block copolymer at different molar ratios. We used Dynamic and Electrophoretic Light Scattering to determine the size and the ζ-potential; imaging techniques for investigate the structure and Static Light Scattering for quantifying the fractal morphology of the prepared nanosystems in situ. The size of mixed nanostructures became smaller with the incorporation of the block copolymer into the lipid membrane.  The size of the prepared nanosystems ranged between 50-80nm. The fractal dimension (df) decreased significantly with the incorporation of block copolymer into liposomal bilayers. The morphology of DPPC:POEGA-PLA mixed nanostructures (with df equal to 1.8) is open (more loose). On the other hand, the morphology of HSPC: POEGA-PLA (with df equal to 2.1) is more compact and dense. The molar ratio of the POEGA-PLA did not alter the morphology of the mixed nanostructures, expect from HSPC:POEGA-PLA system. Finally, we studied the drug loading properties of the mixed nanostructures in order to examine their properties as advanced Drug Delivery nanosystems.  UR - https://aml.iaamonline.org/article_15026.html L1 - https://aml.iaamonline.org/article_15026_5b20f04e334fa99f370746a9e44da187.pdf ER -