TY - JOUR ID - 14668 TI - How Ethanol Treatment Affects The Physico-chemical And Biological Characteristics Of Silk Fibroin Nanofibrous Scaffolds JO - Advanced Materials Letters JA - AML LA - en SN - 0976-3961 AU - Gholipourmalekabadi, Mazaher AU - Mozafari, Masoud AU - Bandehpour, Mojgan AU - Sameni, Marzieh AU - Ghanbarian, Hossein AD - Y1 - 2015 PY - 2015 VL - 6 IS - 5 SP - 391 EP - 394 KW - Silk fibroin KW - Tissue Engineering KW - electrospinning KW - mechanical properties KW - ethanol treatment DO - 10.5185/amlett.2015.5739 N2 - In this study, the effects of ethanol treatment on the mechanical and biological characteristics of the nanofibrous silk fibroin (NSF) scaffolds were evaluated. The results obtained from the mechanical tests confirmed that ethanol treatment significantly enhanced the physical properties of the scaffolds through the formation of a ß-sheet structure. It was shown that the ethanol treatment increased the mechanical property and cell viability, while decreased the porosity of the randomly arranged uniform nanofibers. The ultimate tensile strength for the NSF and ethanol-treated NSF (ET-NSF) scaffolds were 0.76 and 1.33 MPa, respectively. In addition, the ethanol treatment positively affected the proliferation rate of rat bone-marrow stromal cells (rBMSCs) without any detectable cytotoxicity. All the results obtained from this study strongly indicated the efficacy of ethanol treatment in enhancement of mechanical and biological characteristics of silk fibroin nanofibrous scaffolds. UR - https://aml.iaamonline.org/article_14668.html L1 - https://aml.iaamonline.org/article_14668_3dadbedfa8298c51439afb27ae642095.pdf ER -