TY - JOUR ID - 13923 TI - Rectify the Injury-Induced Microenvironment Imbalance in Peripheral Nerve Repair JO - Advanced Materials Letters JA - AML LA - en SN - 0976-3961 AU - Yan, Zhiwen AU - Qian, Yun AD - Y1 - 2020 PY - 2020 VL - 11 IS - 10 SP - 1 EP - 3 KW - Peripheral nerve regeneration KW - nerve guide conduit KW - Regenerative Medicine KW - microenvironment imbalance DO - 10.5185/amlett.2020.101562 N2 - Peripheral nerve injury poses a great threat to the involved individuals’ life quality. Given the situation that the current clinical treatments have limitations, it is urgent to seek for alternative therapies. Artificial nerve guide conduits can bridge nerve gaps and the underlying mechanism is worth studying. In this perspective, we propose that a high-performance nerve guide conduit repairs peripheral nerve by rectifying the injury-induced microenvironment imbalance. And we analyse four different ways to stabilize the disturbed microenvironment: (i) nourish the distal nerve end, (ii) stabilize the immune response, (iii) rectify the energy metabolic disturbance, (iv) restore the bioelectrical signal conduction. UR - https://aml.iaamonline.org/article_13923.html L1 - https://aml.iaamonline.org/article_13923_d6bed7b969bdbe1b689c7638a23f7cb7.pdf ER -