Chetna Verma; Poonam Negi; Deepak Pathania; Sadiya Anjum; Bhuvanesh Gupta
Abstract
Nanogel synthesis is gaining enormous interest in a large number of applications, such as drug delivery, wound care systems and tissue engineering. In the present work, we have investigated the preparation of Tragacanth gum (TG) nanoparticles in a water-in-oil nanoemulsion system. These nanoparticles ...
Read More
Nanogel synthesis is gaining enormous interest in a large number of applications, such as drug delivery, wound care systems and tissue engineering. In the present work, we have investigated the preparation of Tragacanth gum (TG) nanoparticles in a water-in-oil nanoemulsion system. These nanoparticles exhibit stacked core-shell type of structure in which polygonal TG nanoparticles are covered by lipid structured lecithin (LC). The resultant nanoparticles comprise of amphillic nature, i.e. the hydrophilic TG core and hydrophobic LC shell which offers interesting features of immobilization of biomolecules.
Sadiya Anjum; Shamayita Patra; Bhuvanesh Gupta
Abstract
Functional patterning and alignment of metallic nanoparticles are gaining enormous interest in electronics, photonics and sensing areas. In the present work, we have investigated the water-in-oil emulsion polymerization for the growth of functional silver nanoparticles within polyacrylamide chains. These ...
Read More
Functional patterning and alignment of metallic nanoparticles are gaining enormous interest in electronics, photonics and sensing areas. In the present work, we have investigated the water-in-oil emulsion polymerization for the growth of functional silver nanoparticles within polyacrylamide chains. These functional nanoparticles undergo different alignment and patterning with the variation of surfactant concentration. As the surfactant in the emulsion increases, the resultant nanoparticles are linearly aligned into nanofiber with some branching. However, at 10% concentration of surfactant, these fibers are fused and quasi-circular pattern was observed. The average size of the nanoparticles was observed to be in the range of 5 to 25 nm. Whereas, the size of line pattern was observed in some microns with branching or interconnectivity of nanometer range.
Sadiya Anjum; Shamayita Patra; Bhuvanesh Gupta
Abstract
This study is aimed at the development of nanosilver embedded polyacrylamide (PAAm) bioactive nanogels and antimicrobial behavior of these functional nanogels. Nanogels were synthesized by polymerization of the monomer/silver nitrate as water phase in nanoemulsion using gamma irradiation process where ...
Read More
This study is aimed at the development of nanosilver embedded polyacrylamide (PAAm) bioactive nanogels and antimicrobial behavior of these functional nanogels. Nanogels were synthesized by polymerization of the monomer/silver nitrate as water phase in nanoemulsion using gamma irradiation process where radiation helps in the polymerization, nanogel crosslinking and the reduction of silver nitrate to nanosilver. Homogeneously dispersed nanosilver particles embedded within PAAm nanogel matrix having size in the range of 10-50 nm were achieved depending on the reaction conditions. Minimum inhibitory concentration and bacteriostatic efficacy of nanogels were investigated against bacterial strains of Escherichia coli and Staphylococcus aureus. The bioactive nanogels showed very effective antimicrobial behavior and showed mortality against both bacterial strains at very low concentration. The bactericidal action of functional silver nanoparticles against Escherichia coli was investigated by TEM analysis. It was observed that after treatment with bioactive nanogel, the cell wall of Escherichia coli was completely destroyed and punctured. Here, we propose that the bioactive nanogel by virtue of its hydrophilic and polar functionality is very much suitable for linking to different biomaterials for developing antimicrobial surfaces especially in surgical devices and synthetic implants.