Gunther S.V; Dambaev G.Ts; Chekalkin T.L; Kang J-H; Kim J-S; Gunther V.E
Abstract
Despite the prescribed benefits of insulin widely used in treating diabetes, patients still feel the inconvenience and perceived pain related to multiple daily administrations by needle insulin injections. Approved inhaled insulin of the second generation has not so far achieved expectations. Design ...
Read More
Despite the prescribed benefits of insulin widely used in treating diabetes, patients still feel the inconvenience and perceived pain related to multiple daily administrations by needle insulin injections. Approved inhaled insulin of the second generation has not so far achieved expectations. Design of needle-free delivery systems for insulin is an active area of research and this paper reports on the development of a new needle-free approach to deliver insulin treating diabetes. Porous TiNi-based alloys serve as high-density materials being capable of holding insulin solutions within the structure of the material, and infrared radiation promotes the directional diffusion of insulin from the TiNi porous structure into the skin. Taking these two facts into account, the needle-free device (NFD) for delivering insulin uses a new porous-permeable TiNi-based material and a novel infrared radiation mediated delivery system. The NFD described causes no skin irritation or lesions and is safe to use in practice. Its efficiency in delivering insulin was clinically assessed on 42 diabetic patients. The results show promising prospects as a new technology for delivering insulin and other liquid drugs.
Yasenchuk Yu. F.; Artyukhova N. V.; Chekalkin T. L; Anikeev S. G.; Kim Ji-Soon; Kang Ji-Hoon; Gunther V. E
Abstract
Modern medical technologies have developed many new devices that can be implanted into humans to repair, assist or take the place of diseased or defective bones, arteries and even organs. The materials, especially porous ones, used for these devices have evolved steadily over the past twenty years with ...
Read More
Modern medical technologies have developed many new devices that can be implanted into humans to repair, assist or take the place of diseased or defective bones, arteries and even organs. The materials, especially porous ones, used for these devices have evolved steadily over the past twenty years with TiNi-based alloys replacing stainless steels and titanium. The aim of the paper is to presents results for examination of porous TiNiMoCo-based alloy intended further to be used in clinical practice. Porous TiNi-based alloys showing shape memory effect were obtained by the methods of reaction and diffusion sintering with cobalt additives. From the results of the analysis of temperature dependences determined by the measurement of electrical resistivity and shape memory effect test, the effect of cobalt addition on the martensitic transformations in sintered body is described. The addition of cobalt during reaction and, especially, diffusion sintering, results in a decrease in the internal stresses in the TiNi phase. The addition of Co more than 1 at. % led to precipitation hardening of the alloy. Cobalt at concentrations studied in the work led to suppression of martensitic phase transformation.